AM Gómez,^{1– 3} DC Henao-Carillo,^{1– 3} L Taboada,^1,3 O Fuentes,^1,3 O Lucero,^2,3 A Sanko,³ MA Robledo,³ O Muñoz,^2,3 M Rondón,⁴ M García-Jaramillo,⁵ F León-Vargas⁶

¹Endocrinology Unit, Hospital Universitario San Ignacio, Bogotá, Colombia; ²Division of Inside Medication, Hospital Universitario San Ignacio, Bogotá, Colombia; ³College of Medication, Pontificia Universidad Javeriana, Bogotá, Colombia; ⁴Division of Medical Epidemiology, Pontificia Universidad Javeriana, Bogotá, Colombia; ⁵College of Engineering, Universidad EAN, Bogotá, Colombia; ⁶College of Engineering, Universidad Antonio Nariño, Bogotá, Colombia

Correspondence: AM Gómez
Endocrinology Unit, Hospital Universitario San Ignacio, Carrera 7 No. 40-62, Bogotá, Colombia
E mail [email protected]

Background: Excessive glycemic Variability (HGV) has develop into a stronger predictor of hypoglycemia. Nonetheless, scientific components affiliate with HGV nonetheless are unknown.
Goal: To find out scientific variables that had been related to a coefficient of variation (CV) above 36% evaluated by steady glucose monitoring (CGM) in a bunch of sufferers with diabetes mellitus.
Strategies: A cohort of sufferers with sort 2 diabetes (T2D) was evaluated. Demographic variables, HbA1c, glomerular filtration price (GFR) and therapy routine had been assessed. A bivariate evaluation was carried out, to judge the affiliation between the result variable (CV> 36%) and every of the unbiased variables. A multivariate mannequin was constructed to judge associations after controlling for confounding variables.
Outcomes: CGM information from 274 sufferers had been analyzed. CV> 36% was current in 56 sufferers (20.4%). Within the bivariate evaluation, demographic and scientific variables had been included, similar to time since analysis, hypoglycemia historical past, A1c, GFR and therapy established. Within the multivariate evaluation, GFR < 45 mL/min (OR 2.81; CI 1.27,6.23; p:0.01), A1c > 9% (OR 2.81; CI 1.05,7.51; p:0.04) and hypoglycemia historical past (OR 2.09; CI 1.02,4.32; p:0.04) had been related to HGV. Remedy with iDPP4 (OR 0.39; CI 0.19,0.82; p:0.01) and AGLP1 (OR 0.08; CI 0.01,0.68; p:0.02) was inversely related to GV.
Conclusion: Medical variables similar to GFR < 45 mL/min, HbA1C> 9% and a historical past of hypoglycemia are related to a excessive GV. Our information recommend that the usage of expertise and coverings capable of cut back glycemic variability might be helpful on this inhabitants to cut back the danger of hypoglycemia and to enhance glycemic management.

Key phrases: glycemic variability, variation coefficient, steady glucose monitoring, diabetes mellitus