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Coefficient of Variation
Home›Coefficient of Variation›Is the Consensual Threshold for Defining High Glucose Variability Implementable in Clinical Practice?

Is the Consensual Threshold for Defining High Glucose Variability Implementable in Clinical Practice?

By Maureen Bellinger
June 8, 2021
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This article was originally published here

Diabetes Care. 2021 Jun 7:dc201847. doi: 10.2337/dc20-1847. Online ahead of print.

ABSTRACT

OBJECTIVE: Estimating glycemic variability (GV) through within-day coefficient of variation (%CVw) is recommended for patients with type 1 Diabetes (T1D). High GV (hGV) is defined as %CVw > 36%. However, continuous glucose monitoring (CGM) devices provide exclusively total CV (%CVT). We aimed to assess consequences of this disparity.

RESEARCH DESIGN AND METHODS: We retrospectively calculated both %CVT and %CVw of consecutive T1D patients from their CGM raw data during 14 days. Patients with hGV with %CVT >36% and %CVw ≤36% were called the “inconsistent GV group”.

RESULTS: A total of 104 patients were included. Mean ± SD %CVT and %CVw were 42.4 ± 8% and 37.0 ± 7.4% respectively (P < 0.0001). Using %CVT, 81 patients (73.6%) were classified as having hGV, whereas 59 (53.6%) using %CVw (P < 0.0001) corresponding to 22 patients (21%) in the inconsistent GV population.

CONCLUSIONS: Evaluation of GV through %CV in patients with T1D is highly dependent on the calculation method and then must be standardized.

PMID:34099517 | DOI:10.2337/dc20-1847

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