COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

[ad_1]
A.K.S., A.-C.V., I.S.V., Z.G.J., O.R.-R. and A.R. conceived and led the study. These authors contributed equally as co-second authors: Z.B.-A., N.B., A.G., J.G., J.C.M., I.K., E.N., P.N., Y.V.P., S.S.R., S.N., L.T.-Y.T., K.J.S., M.Su., V.M.T., S.K.V., Y.W. T.M.D., C.G.K.Z., à .S., D.A. designed protocols and carried out experiments together with D.P., Z.B.-A., V.M.T., A.S., S.Z., J.G., J.H., E.N., M.Su., C.M., L.T., A.E., D.Pa., L.P., J.C.M., L.A.-Z. C.B.M.P., C.G.K.Z., O.A., R.N., G.H., K.J., K.S., B.L., Y.Y., S.F., A.S., P.N., Y.P.J., P.N., T.He., J.R., W.H., I.S.V., T.M.D. and J.B. designed and performed computational analysis. M.B., N.B., J.G., Y.W., R.G., S.S.R., H.M., P.S., A.W., C.M., M.L.-G., T.H., D.T.M., S.W., D.R.Z., E.R., M.R., E.M., R.F., P.Di., A.G., C.Pe. and M.N. provided input to and assisted with computational analysis. K.J., K.D., A.G., J.E., S.G., A.R. and A.P. contributed methods and performed integrated analysis for GWAS. P.R.T., D.T.M., Z.G.J., Y.P., G.S., S.N., S.R. and J.R. provided clinical and biological expertise. D.F., D.J., D.E.M., C.P., S.K.V., E.K. and J.S. provided clinical expertise, performed sample acquisition and/or administrative coordination at MGH. J.H., R.R., R.N., O.R.B., Z.G.J., Y.P. and D.I. provided clinical expertise, performed sample acquisition and/or administrative coordination at BIDMC. I.H.S., D.A., L.C., J.G., R.P., M.Si., provided clinical expertise, performed sample acquisition and/or administrative coordination at BWH. I.G., H.H. and B.I. provided clinical expertise, performed sample acquisition and/or administrative coordination at CUIMC/NYP. P.D., D.P., J.J-V. and J.B. helped with sample coordination and sample receipt at the Broad Institute. N.B and S.R. performed bulk RNA-Seq deconvolution analysis. E.N., M.R. and K.S. performed viral qPCR, whole-genome sequencing and phylogenetic analyses. M.S. provided input for sc/snRNA-Seq experiments and protocols. J.J.-V., E.T., O.R.R. and A.-C.V. managed the study and tissue acquisition. T.L.T. contributed computational expertise and advice. T.M.D., C.B.M.P., C.G.K.Z., G.H., R.N., K.J., O.A., B.L., Z.G.J., I.S.V, Y.Y., S.F., A.S., D.T.M., A.K.S., A.-C.V., O.R.-R. and A.R. wrote the manuscript, with input from all authors. D.H., P.C.S., N.H. and P.T.E. supervised research.
[ad_2]